Check Out Acronyms on Destiny 2 Wiki
3oC - Three of Coins
Adds - Additional enemies that spawn during boss fight
ADS - Aim Down Sights
AE - Atheon's Epilogue
AFK - Away from Keyboard
Aggro - Drawing the attention of enemies
Alt - Alternative Character
AoE - Area of Effect
AoT - Age of Triumph
AR - Auto Rifle
Burn - Focus fire on a specific enemy, usually a boss
CC - Crowd Control
CoE - Challenge of the Elders
CoO - Court of Oryx
Crit - Critical Hit
DO - Dead Orbit
DoT - Damage over Time
DPS - Damage per Second
FB - Fatebringer
FR - Fusion Rifle
FWC - Future War Cult
G-Horn - Gjallarhorn
HC - Hand Cannon
HM - Hard Mode or Hawkmoon
HoW - House of Wolves
IB - Iron Banner
INC - Incoming
IRL - In Real Life
LFG - Looking for Group
LFM - Looking for Member
LHF - Lord High Fixer
LoS - Line of Sight
Main - Main Character
MG - Machine Gun
Mobs - Mobile, non-boss enemies
MoL - Mote of Light
NF - Nightfall
NM - New Monarchy or Normal Mode
NPC - Non-player Character(s)
OMW - On My Way
OP - Overpowered
PC - Plan C
PI - Pocket Infinity
PoE - The Prison of Elders
Proc - Something occuring
PuG - Pick up Group
P&T - Patience and Time
QW - Queen's Wrath
Randy - Random Player
RL - Rocket Launcher
RNG - Random Number Generator
RoI - Rise of Iron
SC - Strange Coin
SGA - Super Good Advice. Can be used in place of PSA (Public Service Announcement) or Pro Tip
SR - Speed Run
SRL - Sparrow Racing League
TDB - The Dark Below
TDYK - The Devil You Know
TLW - The Last Word. Can be used in place of TL;DR (Too Long Didn't Read)
ToO - Trials of Osiris
Trash - non-boss enemies
TTK - The Taken King
VoC - Vision of Confluence
VoG - Vault of Glass
VR - Virtual Reality
Y1 - Year 1
Y2 - Year 2